Games that rely on a save point feature, where the save points are very far apart.
Seriously, I just want to get to a save because it's 3 AM and I need to go to work in a few hours, why do I have to beat a boss after almost an hour of getting there in order to save?!
Also, whenever a modern console/PC game, especially one that you paid for, starts pushing you to buy DLC for upgrades and stuff. That stuff drives me bonkers. I get this in Free-to-Play games, where that's how they get their money, but even there it can get excessive and annoying. And it really has no business being in full-priced games like Assassin's Creed Unity or Metal Gear Solid V.