Interesting topic.
Personally Roddenberry's Andromeda has been one of my most favorite sci-fi series (at least the first two seasons anyway before creative control was stolen from the show's head writer and executive producer Robert Hewitt Wolfe)
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[taken from the Andromeda Wiki article "Systems Commonwealth"]
The All Systems Commonwealth, Systems Commonwealth, or the Commonwealth, is a democratic federation of 1,022,347 planets, drifts, space stations, various orbital habitats, and even entire solar systems.
The Commonwealth was a federal state created from the Vedran Empire. The Vedrans, a quadruped race originating from planet Tarn-Vedra, were the first known race to discover Slipstream, the only known way to travel faster-than-light. The Vedrans built their empire by traveling to the different star systems and conquering the inhabitants and colonizing the uninhabited worlds. However, the empire soon became too large, with the Vedrans being a statistical minority in their own empire. The Vedrans came to a compromise with the alien species that they had relations with or had conquered, and the Commonwealth was created. The Commonwealth was formed as a democratic federation of planets, drifts (space stations or orbital habitats), and systems. The Commonwealth (and its preceding Empire) was spread across three galaxies ("Tri-Galaxies").
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What I like about this is that it makes it very clear that it's the Vedran's who created the Commonwealth and Humanity is just one of the member species.
Much as I love Star Trek (still waiting on my replicator scientists, you're close but hop to it!

) the one thing that bothered me regarding the lore is that humanity has such a high and mighty noble position as the species who slapped the others in the galaxy together and got them to make the United Federation of Planets.
Which is cool and all, that's part of Trek lore, it's a "best of all possible worlds" situation for humanity. An idyllic and utopian future for us.
Call me pessimistic or just a realist but I like stories where humanity isn't the main player on the stage but is instead just another extra in the play of life.